CHI3L1 and amyotrophic lateral sclerosis: Thompson and colleagues [72] measured the levels of chitinase proteins Chitotriosidase-1 (CHIT1), Chitinase-3-like protein 1 (CHI3L1), and Chitinase-3-like protein 2 (CHI3L2) in cerebrospinal fluid (CSF) in ALS, founding only a weak association between higher CHI3L1 levels and worst ECAS score.