Analysis of differentially expressed genes (DEG) with DAVID functional annotation module and Gene Set Enrichment Analysis (GSEA) revealed that Inpp4b deletion affected lipid and glucose metabolisms, drug detoxification, peroxisome biogenesis, and expression of the T2D-associated genes (Fig. 5a, b and Supplementary Data 2). The gene discussed is INPP4B; the disease is type 2 diabetes mellitus.