Similar to our HFD Inpp4b−/− male mice, gene expression analysis in the livers of non-diabetic (N = 9) and T2D obese individuals (N = 9) (GSE15653) revealed that INPP4B expression was decreased in the obese, diabetic group (Fig. 3e)34. This evidence concerns the gene INPP4B and type 2 diabetes mellitus.