CENPA and cervical squamous intraepithelial neoplasia: However, on a longer timescale, we observed an increase in mitotic stress associated with CENP-A overexpression that was similar in both p53-WT and p53-DN cells (micronuclei in Fig. 4f, and CIN in Supplementary Fig. 3E, including numerical and structural aneuploidy by multicolor fluorescence in situ hybridization (mFISH) karyotypes).