To further elucidate the mechanisms governing macrophage inflammatory response in atherosclerosis, we examined gene expression changes from LXRα WT and LXRα S196A plaque CD68+ cells collected by laser-capture microdissection by performing bulk RNA sequencing (RNA seq)29 (Supplementary Fig. S7A and Supplementary Data 2). The gene discussed is NR1H3; the disease is atherosclerosis.