NR1H3 and obesity due to melanocortin 4 receptor deficiency: In this study, we examined the impact of LXRα pS196 in immune cells on atherosclerosis progression and obesity, using a bone marrow transplant approach from wild type (WT) and LXRα S196A knock-in mice, which are unable to be phosphorylated and should retain only the anti-inflammatory actions of LXRα.