APLN and atherosclerosis: IPA of the genes induced by LXRα S196A in plaque T cells identified cholesterol biosynthesis, which is crucial for efficient T cell activation and T reg differentiation41, apelin signaling, which has been shown to attenuate atherosclerosis mediated by angiotensin II42, glycoprotein VI, which impacts platelet function43, Wnt/β-catenin, which play key roles in T cell differentiation, polarization and survival44, and Integrin-linked kinase (ILK) signaling, which has been reported to promote T-cell trafficking and survival45.