CREBBP and autosomal dominant cerebellar ataxia: These 20 prion-like candidates include proteins whose polyQ expansion is connected to autosomal dominant cerebellar ataxia, such as the TATA-box-binding protein (TBP) and ATXN111, as well as the CREB-binding protein (CBP), a transcriptional coactivator necessary for the survival of many neurons which is recruited into aggregates in polyQ diseases36.