ANGPTL3 and familial hypercholesterolemia: At least 5 different loci have been associated with rare cases of monogenic FCHL: LDLR16,17, LPL15, APOE34, PCSK935 and APOA536,37, but ANGPTL3 does not appear to be associated with this form of FCHL nor familial hypercholesterolemia (FH).