ANGPTL3 and familial hypobetalipoproteinemia 2: These results contrast with the role of ANGPTL3 in the lipid phenotype called familial combined hypolipidemia (FHBL2, OMIM #605019)20, in which LOF mutations in ANGPTL3 are responsible of reduced plasma levels of TC, TG, VLDL cholesterol, LDLc, apoB, and free fatty acids, just the opposite lipid profile found in FCHL.