These results contrast with the role of ANGPTL3 in the lipid phenotype called familial combined hypolipidemia (FHBL2, OMIM #605019)20, in which LOF mutations in ANGPTL3 are responsible of reduced plasma levels of TC, TG, VLDL cholesterol, LDLc, apoB, and free fatty acids, just the opposite lipid profile found in FCHL. The gene discussed is APOB; the disease is familial hypobetalipoproteinemia 2.