More interestingly, different expression patterns were also observed among ccRCC tumors where pS727-STAT3 was i) only present in the nucleus (Fig. 1a), ii) completely cytosolic (Fig. 1b), or iii) simultaneously detected in both cellular compartments (Fig. 1c) but without a significant correlation between their independent H-scores (p = 0.2). Here, STAT3 is linked to nonpapillary renal cell carcinoma.