In the present study, patients who received adjuvant treatment (n = 15) in response to recurrence after surgery were found included in the high nuclear pS727-STAT3 levels group (H-score ≤ 80) and advanced stages of the disease according to Fuhrman grade III-IV and tumor size pT3-4, N1,2 M1. Here, STAT3 is linked to neoplasm.