STAT3 and neoplasm: Kaplan–Meier estimates of mortality (120 months overall survival) showed statistically significant differences in overall survival rates between patients in the same advanced-stage clinicopathologic group with high versus low pS727-STAT3 H-score: Fuhrman grade III–IV (nuclear p = 0.005, cytosolic p = 0.027), high-risk group (nuclear p = 0.018, cytosolic p = 0.005), and tumor size pT3-4 N1,2 M1 (nuclear p = 0.009, cytosolic p = 0.012) (Fig. 2a,b).