STAT3 and nonpapillary renal cell carcinoma: Based on this study and our observation that ccRCC patients with a high pS727-STAT3 expression which undergone TKIs treatment experienced a significant stabilization of the disease (~ 20 months), we postulated that determination of pS727-STAT3 levels at the time of surgery could indicate that patients with localized tumors might benefit from adjuvant treatment versus those that only will suffer the adverse effects.