RAPGEF4 and cancer: We also found some different related genes, such as cell adhesion related genes (ITGBL1, RAPGEF4, ADGRL3, CDH18, DCAF6, CUTA) in late-stage cancer group (Supplementary Table S2a, b, c), BCAR1 in ER positive group (Supplementary Table S3a, b) and some genes (ADCY2, CALM2, HSPA2, HSP90AA1, PIK3CA, AKT3 and SHC4) related to estrogen signaling pathway in luminal A group (Supplementary Tables S4a, b and S5a, b).