Our in vivo study in mice showed a high level of proinflammatory cytokine expression, including IL-1β, IL-2, IL-6, IL-12/23p40, IL-15/15R, IL-17A, IL-22, and IFNγ, 6 h after intraperitoneal (i.p.)injection of rpHSP70-AD. Here, IL22 is linked to Alzheimer disease.