As for the levels of P RNA, infection of Hep3B-CSDE1C-T with VSV-IFNβ-IGR P/MC-U completely normalized the levels of M RNA and protein, showing that the negative effects of CSDE1P5S on transcription of viral M RNA were compensated by the presence of the IGR P/MC-U mutation in the viral genome (Fig. 3B). Here, IFNB1 is linked to infection.