We have previously developed a murine model in which mammary gland expression of Met (MMTV-Metmt)34 and loss of the tumour suppressor gene Trp53 (MMTV-Metmt;Trp53fl/+;Cre) synergise to promote tumours displaying a spindloid, mesenchymal pathology associated with the molecular and pathological features of claudin-low breast cancer36. This evidence concerns the gene TP53 and neoplasm.