Tumoursphere proliferation, measured by Cyquant proliferation assays after 7 days in culture, revealed that all spindloid tumour cell lines, including those derived from Trp53fl/+;Cre tumours (which spontaneously amplified the endogenous murine Met locus36), showed a significant reduction in sphere proliferation when treated with both inhibitors when compared to either inhibitor alone (Fig. 2d). Here, MET is linked to neoplasm.