Analysis of DepMap CRISPR knockout screening data matched with available molecular data from the Cancer Cell Line Encyclopedia (CCLE) provided independent confirmation that the SUM52PE cell line with strong amplification and AAMDC overexpression had a greater dependence on AAMDC for cell survival relative to other luminal BC lines that do not harbor the AAMDC amplification (Supplementary Fig. 1d). Here, AAMDC is linked to cancer.