We also performed fluorescence in situ hybridization and detected that the decrease in miR-135a-5p expression is prominent in CaMKII-positive neurons (Fig. 1d, e) but not in GAD67-positive neurons (Supplementary Fig. 1a), suggesting that the loss of miR-135a-5p in AD mainly occurs in excitatory neurons. This evidence concerns the gene CAMK2G and Alzheimer disease.