Moreover, siP-Add1 administration not only significantly restored the density of dendritic spines (Fig. 7d–f) and the complexity of neuronal dendrites (Fig. 7g-i) but also ameliorated LTP and LTD deficits (Fig. 7j, k, Supplementary Fig. 8k–m) and memory impairments (Fig. 7l–o) in AD model mice. Here, ADD1 is linked to memory impairment.