Within these clusters and following differential expression analysis we found genes related to cancer invasion such as Col3a1, Map4k4, Chd7 and Tubb2b27–29, genes associated with proliferation and tumor progression such as Pdgfa and the oncogenes Fos, Jun and Myc30–33, and angiogenesis genes as VEGFa, Tcf4, Timp1 and Timp334–37 (Fig. 6D). This evidence concerns the gene COL3A1 and cancer.