TEFM knockdown significantly increased the levels of epithelial markers (E-cadherin and ZO-1), while decreased the levels of mesenchymal markers (N-cadherin and Vimentin) in SNU-354 and SNU-739 cells (Fig. 3C, D), suggesting that TEFM may facilitate the migration and invasion of HCC cells through induction of EMT. The gene discussed is TJP1; the disease is hepatocellular carcinoma.