CCL3 and leukemia: In the initiation step of chronic myeloid leukemia (CML) development, we demonstrated that CML LIC-derived basophil-like leukemia cells constitutively secrete an inflammatory chemokine, CCL3, which has a potent capacity to inhibit normal hematopoiesis, thereby indirectly promoting leukemia-tropic hematopoiesis in the limited bone marrow (BM) space in CML-bearing mice2,3.