Moreover, Hwang et al. recently reported that both SBI-0206965 and MRT-68921 could induce degradation of internal tandem duplication mutations in the FLT3 tyrosine kinase receptor (FLT3-ITD) protein, thereby exerting cytotoxicity in FLT-ITD AML cells31. Here, FLT3 is linked to acute myeloid leukemia.