PTEN and sudden cardiac arrest: It is able to antagonize the effect of PTEN over-expression, enhance the activity of PI3K/AKT signaling pathway, and alleviate myocardial cell apoptosis87, and it is also able to inhibit the expression of pro-inflammatory cytokines IL-1β and TNF-α and up-regulate anti-inflammatory IL-10 expression in a sudden cardiac arrest model88.