In addition, chronic administration of the antidepressants enhances adult hippocampal neurogenesis in rodents1,48,49, The increased 5-HT neuron activity and reduced depression-like behaviors in Pten cKO mice resembles the effect of SSRI antidepressants, and we investigated the BDNF expression and neurogenesis in the hippocampus. Here, PTEN is linked to major depressive disorder.