AKT1 and neoplasm: PTEN is a well-known tumor suppressor that acts as a phosphatase for the lipid signaling intermediate phosphatidylinositol-3,4,5-triphosphate, and that inactivates the phosphatidyl inositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway7,8.