MEG3 and Hepatic fibrosis: Linc-SCRG1 exhibits a promoting effect on HSC activation and contributes to human liver fibrosis.18 LincRNA-p21 sponges miR-17-5p and miR-17-5p to inhibit Wnt/β-Catenin pathway, thus inactivating HSCs.19 MEG3 blocks the activation of HSCs and alleviates liver fibrosis by interacting with miR-212 and smoothened (SMO) protein.20 Moreover, lncRNAs have been widely reported to participate in the competitive endogenous RNA (ceRNA) network.