Here, we show that the kinesin-1 adapter fasciculation and elongation protein zeta 1 (FEZ1) forms complexes with collapsin response mediator protein (CRMP)1 or deleted in colorectal cancer (DCC), which are downstream effectors of the Sema3A and Netrin-1 signaling pathway, respectively. The gene discussed is DCC; the disease is colorectal cancer.