DCC and colorectal cancer: Chemoattractive signaling effected, for instance, via Netrin-1 through its receptors deleted in colorectal cancer (DCC) and Down’s syndrome cell adhesion molecule (DSCAM), is responsible for the attraction of commissural axons toward the midline in the spinal cord (Kennedy et al., 1994; Serafini et al., 1994; Keino-Masu et al., 1996; Ly et al., 2008).