House dust mite-induced allergic rhinitis (HDM-AR) is an IgE-mediated immune response occurring in the mucosal lining of the nasal cavity, evidenced by a clinical history of rhinitis symptoms (sneezing, nasal pruritis, rhinorrhea, and nasal congestion) and/or ocular symptoms (itchy, teary and red eyes) upon HDM exposure, with a positive skin prick test or nasal provocation test and specific IgE testing [5, 13]. The gene discussed is IGHE; the disease is rhinitis.