Especially relevant to neurodegenerative disorders is the finding that FKBP5 expression has been shown to progressively increase with normal aging, concomitant with reduced FKBP5 DNA methylation [53], which correlated with Braak staging in human brains and increased tau pathology both in vitro and in mouse models of AD [53, 54]. The gene discussed is FKBP5; the disease is Alzheimer disease.