Several studies have stated that various molecules, such as choline kinase alpha (CHKA), reticulocalbin-2 (RCN2), MUC15, and versicanV1, could promote HCC proliferation or metastasis and induce EGFR antagonist resistance by interacting with EGFR and activating the EGFR signalling [41–44]. The gene discussed is EGFR; the disease is hepatocellular carcinoma.