Another study showed that LINC00857 regulated the progression of lung cancer through cell cycle regulation [35], there was also a study indicated that cell cycle, Hippo, TGFβ, and p53 pathway alterations were associated with poor disease-free survival (DFS) in early-stage LUAD [36], these results consistent with our results that cell cycle and p53 signaling pathway were the predicted pathways. The gene discussed is LINC00857; the disease is lung cancer.