The phytotoxity and side effects of MtNPs that have been reported so far in crops include disturbances in water transfer, decreased photosynthetic rate, decreased growth hormone production, metabolic disorders, increased oxidative stress, chromosomal abnormalities, decreased growth, transcriptional changes in several genes and hypersensitivity to natural toxins such as arsenic [172, 185]. Here, GH1 is linked to Other metabolic disease.