The results revealed that in 372 cases of HCC patients, PRDX1 and PRDX4 were altered in 26 cases (7%), PRDX2 and PRDX5 were altered in 33 cases (9%), PRDX3 was altered in 40 cases (11%), and PRDX6 was altered in 63 cases (18%). This evidence concerns the gene PRDX5 and hepatocellular carcinoma.