ARC and eye disorder: We also identified potential ARC candidate genes previously shown to be involved in the occurrence and development of a variety of eye diseases, but not ARC, such as ANGPTL4. Aberrant ANGPTL4 expression levels are associated with branch retinal vein occlusion, macular edema, and age-related macular degeneration diseases, and are considered to be a biomarker and therapeutic target for retinopathy caused by ischemia [21, 22].