Stratified by genotypes and adjusting age and disease duration, female sex showed milder ADL impairment (OR = 0.610, P = 0.021), lower risk of EDS (OR = 0.555, p = 0.007), lower risk of SN + (OR = 0.448, P = 0.019), lower risk of autonomic dysfunction (OR = 0.626, p = 0.016) and higher risk of mood disorders (OR = 1.691, p = 0.022) in non-carriers compared with male in LRRK2 G2385R non-carriers (Table 3). The gene discussed is LRRK2; the disease is Abnormal autonomic nervous system physiology.