Some research reported more frequent subtype of postural instability/gait difficulty and motor fluctuation in patients with LRRK2 G2385R variant [15, 16], but no major clinical differences except for the non-significant milder non-motor symptoms were found in PD patients with LRRK2 in most previous studies [13, 17, 18]. The gene discussed is LRRK2; the disease is Parkinson disease.