The safety and efficacy of BAT in subjects with systolic HF was further evaluated in the recent Baroreflex Activation Therapy for HF (BeAT-HF) trial [7, 8] Six-month data show that patients receiving BAT plus guideline directed therapy (BAT + GDT) significantly reduced NT-proBNP levels by 21% (p = 0.002) over a 6-month period from a median baseline value of 688 pg/mL, while patients with GDT alone showed an increase in NT-proBNP of 3% (p = n/s) from a median baseline value of 784 pg/mL, a 25% relative reduction (p = 0.004). This evidence concerns the gene NPPB and hydrops fetalis.