In particular, TAZ and YAP interact with transcription factors, in particular, transcriptional enhanced associate domain (TEAD) family and enhance the transcription of multiple targets involved in tumorigenesis, thereby affecting the self-renewal of stem cells, tumor progression, metastasis, and drug resistance (Chan et al. 2009; Zanconato et al. 2015, 2016; Lin et al. 2017). Here, WWTR1 is linked to neoplasm.