The role of eosinophils in the pathogenesis of ILD has not been comprehensively understood yet: cytokines involved in eosinophil activation like Interleukin(IL)-4, IL-5, IL-13 or IL-33 also play a major role in the pathophysiology of IPF and SSCILD [10, 35, 38, 39]. The gene discussed is IL33; the disease is idiopathic pulmonary fibrosis.