The comparison between our simulated results with Model 6 and the clinical study of Rabasa-Lhoret et al. [44] demonstrated similar qualitative changes in glucose levels during and post-exercise, leading to similar clinical conclusions regarding hypoglycemia risks with different exercise intensities (25–75% VO2max), durations (30–60 min), and pre-meal insulin bolus reductions (25–75% reductions). This evidence concerns the gene INS and Hypoglycemia.