Next, using Hypertension as an exemplar age-associated complex disease, we assessed the association of detected TF-SNP interactions with Hypertension in eight tissues (Adipose-Subcutaneous, Whole Blood, Artery—Aorta, Lung, Adipose-Visceral, Heart-Left Ventricle, Heart-Atrial Appendage, Artery-Coronary) that are implicated in hypertension. The gene discussed is TF; the disease is hypertensive disorder.