BRAF and melanoma: The wide peak annotated by HIPK2 and TBXAS1 contains 72 genes, including BRAF. BRAF amplification is a mechanism of acquired resistance to BRAF inhibitors in BRAFV600E melanomas (Corcoran et al,2010; Villanueva et al,2013; Nathanson et al,2013; Stagni et al,2018).