Unlike CDKN2A and TP53, PTEN was inferred to exclusively cooperate with BRAF. Supporting the minimal sufficiency of BRAF‐M + PTEN‐MD, co‐occurrence of BRAFV600E and PTEN loss was shown to induce metastatic melanoma in mouse models, while BRAFV600E alone only produced benign nevi in the mice (Dankort et al,2009). This evidence concerns the gene TP53 and metastatic melanoma.