CDKN2A and metastatic melanoma: Unlike CDKN2A and TP53, PTEN was inferred to exclusively cooperate with BRAF. Supporting the minimal sufficiency of BRAF‐M + PTEN‐MD, co‐occurrence of BRAFV600E and PTEN loss was shown to induce metastatic melanoma in mouse models, while BRAFV600E alone only produced benign nevi in the mice (Dankort et al,2009).