As Sdc3 deletion leads to a bone phenotype mimicking premature osteoporosis, which in humans is typically associated with increased bone marrow adipose tissue (BMAT), we quantified BMAT, seen as empty spaces in the bone marrow on the Goldner's Trichrome stain, after the void areas had been confirmed to contain adipocytes on perilipin staining (Figure 5A). Here, SDC3 is linked to osteoporosis.