CD274 and neoplasm: In the effort to determine the conditions for the therapy improvement, the expression of PD-L1, ligand for the receptor PD-1 [11] has been also made up, both on tumour cells and in infiltrating lymphocytes: in some recent studies, high amounts of PD-L1+ lymphocytes predict a better prognosis, whilst tumour cells positivity seems not to be significant [9,12].