In the new WHO classification, the high-grade B-cell lymphoma has been redefined, including in this subgroup the entities carrying MYC rearrangement (MYC-R) associated to BCL2 rearrangement (BCL2-R) and/or BCL6 rearrangement (BCL6-R) named as double- and triple-hit lymphomas [1]. The gene discussed is BCL6; the disease is lymphoma.