Thus, the combination of MYC alterations with BCL2- and/or BCL6- rearrangements led to the definition of a new diagnostic subgroup of high-grade B-cell lymphomas (HGBLs) regardless of its morphological features; thus, in this group, lymphomas previously defined as having morphology/phenotype indeterminate between DLBCL and Burkitt lymphoma were included. This evidence concerns the gene MYC and lymphoma.