TMEM180 is also known as MFSD13A (Major Facilitator Superfamily Domain Containing13A) and it encodes a transmembrane protein which contains 12 transmembrane domains.80 Previous studies have showed that TMEM180 knockdown (with siRNAs) promotes proliferation of the human pancreatic cancer cells.81 In addition, TMEM180 is highly expressed in colorectal cancer cells80 and it may be a new marker for colorectal cancer.82,83 To date, the exact function of TMEM180 is still unclear and we know little about the role of TMEM180 in brain and schizophrenia pathogenesis. The gene discussed is SLC68A1; the disease is colorectal cancer.