ACTR1A and schizophrenia: In this study, we performed integrative analyses using genome-wide associations of schizophrenia (22 778 schizophrenia cases and 35 362 controls) and eQTL data (162 individuals) from populations of EAS ancestry.11,30 We first conducted a TWAS31 in EAS and identified 4 transcriptome-wide significant risk genes (including TMEM180, ACTR1A, SFXN2, and MAD1L1) for schizophrenia (corrected by Bonferroni multiple comparison testing) (table 1), and TMEM180 showed the most significant association (TWAS P = 2.89 × 10–14).