RPL5 and Diamond-Blackfan anemia: For example, Diamond-Blackfan anemia (DBA) causes defective erythropoiesis due to genetic perturbations in ribosomal genes, such as RPS19 or RPL5. Patient-derived iPSCs recapitulate early hematopoietic defects associated with this disease, including progenitor apoptosis and erythroid maturational arrest [35].