Figures 1a and 1b show that systemic and intracranial uromodulin decreased with age (p<0.0001 and r2=0.343, p=0.0416 and r2=0.102). Figure 2a shows systemic uromodulin expression increased with BMI>25 (p=0.0139) while figure 2b shows no significant change in intracranial expression. The relationship between systemic and intracranial uromodulin expression and the presence of acute ischemic stroke were assessed. Figures 3a and 3b show that systemic and intracranial uromodulin expression decreased with hypertension, p=0.0177 and p=0.0066 respectively. This evidence concerns the gene UMOD and Hypertension.