These results suggested that VB could stimulate the secretion of exosomes by GBM cells to subsequently transfer miR-7-5p to other GBM cells and that VB could regulate the PI3K/AKT signaling pathway by targeting EGFR; meanwhile, the tumor-inhibiting role of VB could be counteracted by miR-7-5p inhibition. Here, EGFR is linked to neoplasm.