DHX58 and Down syndrome: Among these DEGs, the highest-ranked upregulated genes included DEXH (Asp-Glu-X-His) box polypeptide 58 (DHX58), integrin-alpha 2 (ITGA2), and 2'-5'-oligoadenylate synthetase 2 (OAS2), whereas the lowest downregulated genes comprised of myosin VIIA (MYO7A), Usher syndrome 1C (USH1C), and chemokine (C-X-C motif) receptor 6 (CXCR6) (Figure 2).