NPPB and congenital rubella syndrome: While our new type 6 CRS is based—except for disease acuity and sequential organ involvement—on detectable and visualized markers of cardiac injury including BNP and myocardial enzyme spectrum, renal function markers such as creatinine, Cys-C, and key pathophysiological markers of fibrosis of cardiorenal chronic co-impairment, together with imaging and pathological examination to make an integrated diagnosis, for which our novel pragmatic CRS categories facilitate a differentiation diagnosis from various subtypes and streamline inclusion criteria for future clinical trials.