Recently, the relationship between cardiovascular disease and heparin-binding protein (HBP) was confirmed by using bioinformatics methods (Cai et al., 2020), which showed that HBPs may act as a novel biomarker linking cardiovascular diseases, such as atherosclerosis, myocarditis, myocardial ischemia, and myocardial infarction (MI). This evidence concerns the gene AZU1 and myocardial ischemia.