For example, heparin tetrasaccharides specifically block the interactions of L- and P-selectins with antigen sialyl Lewis X-containing ligands, which show anti-inflammatory activity in vivo and prevent the adhesion of colon cancer cells to L- and P-selectin (Norgard-Sumnicht et al., 1993). The gene discussed is SELP; the disease is malignant colon neoplasm.