Monocyte chemoattractant protein-1 (MCP1) which molds the tumor microenvironment and promotes tumorigenesis (Yoshimura, 2017) was shown to increase significantly in recipient THP1 monocytes after co-culture of exosomes derived from CAL27 (Momen-Heravi and Bala, 2018). This evidence concerns the gene CCL2 and neoplasm.