IER3 and cancer: The first five core paths of COVID-PF are IL-10 signaling; constitutive signaling by aberrant PI3K in cancer; PI3K/AKT signaling in cancer; PI5P, PP2A, and IER3 regulate the PI3K/AKT signaling; and transcriptional regulation by the AP-2 (TFAP2) family of transcription factors.