MEIS1 is upregulated in many human cancers, including the majority of acute myeloid leukemias (AML), whereas PREP1 has tumor-suppressive properties (Lawrence et al., 1999; Longobardi et al., 2010; Blasi et al., 2017; Schulte and Geerts, 2019). The gene discussed is PKNOX1; the disease is acute myeloid leukemia.