MEIS1 is upregulated in many human cancers, including the majority of acute myeloid leukemias (AML), whereas PREP1 has tumor-suppressive properties (Lawrence et al., 1999; Longobardi et al., 2010; Blasi et al., 2017; Schulte and Geerts, 2019). This evidence concerns the gene MEIS1 and acute myeloid leukemia.