Indeed, elevated numbers of CD3+ T-cells, CD20+ B-cells, and CD68+ macrophages, along with a concomitant decrease in the numbers of regulatory T-cells (Tregs) were also observed using IHC in synovial biopsies from RA patients with high disease activity scores compared to patients with lower disease activity or in remission (Zhang et al., 2005; Behrens et al., 2007; Alivernini et al., 2017). The gene discussed is CD68; the disease is rheumatoid arthritis.