IGF-1 could trigger tumor cell growth and invasiveness of PC cells leading to promoting activation of PI3K/AKT/NFκB signaling as well as downregulating phosphorylation of PTEN. PTEN knockdown via siRNA could increase PI3K/AKT/NFκB pathway activation and increasing tumor cell proliferation and invasion. The gene discussed is NFKB1; the disease is pachyonychia congenita.