IGF1 and brain neoplasm: Also, Vewinger et al. have illustrated that the IGF signaling pathway has an important role in HGNET-BCOR brain tumor since IGF-1R could be a significant target to improve the sensitivity of vinca alkaloids, vinblastine, doxorubicin, ceritinib, and actinomycin D as efficient drugs in patients affected with this kind of brain tumor.