IGF1 and neoplasm: Via applying a CRISPR/Cas9 or siRNA genome editing tool, it could be possible to knock out or edit ectopic expression of various genes related to IGF signaling cascade through which we could be able to improve response to chemotherapeutic agents as well as attenuating tumor cell survival, proliferation, invasion, angiogenesis, and metastasis of different kinds to a large extent (Singh et al., 2008; Brouwer-Visser et al., 2014; Hussmann et al., 2017; Strub et al., 2018).