Overexpression of miR-4458 by decreasing both total IGF-1R and phosphorylated IGF-1R could lead to a decrease of phosphorylated AKT. Also, miR-4458 by suppressing the PI3K/AKT pathway via inhibiting IGF-1R could promote the development of LDD. The gene discussed is IGF1R; the disease is Lhermitte-Duclos disease.