Dual knockdown of FAK and IGF-1R via TAE 226 and siRNA could lead to remarkable suppression of cell viability, reducing ERK and AKT phosphorylation levels, and promoting apoptosis in PC cells which in turn resulting in caspase-3 activation as well as ADP-ribose and PARP cleavage in tumor cells. Here, CASP3 is linked to pachyonychia congenita.