Upregulation of IGFBP3 through applying 5AZA treatment resulting in inhibiting cancer cell survival, triggering tumor cell death, decrease colony formation and invasion, inducing expression of the pro-apoptotic genes containing PUMA, p21, and BAX as well as caspase 3 cleavage and downregulating phosphorylation of AKT (Dar et al., 2010). Here, IGFBP3 is linked to cancer.