JAK2 and chronic myelogenous leukemia, BCR-ABL1 positive: In AML, ADAR1 is variably expressed (100) and a JAK2-dependent upregulation of ADAR1 p150 takes place during blast crisis in chronic myeloid leukemia (CML) (101), but there is a lack of correlations between ADAR1 levels and activity and clinical outcomes.